Cast

• Tobey Maguire Spider-Man / Peter Parker
• Kirsten Dunst Mary Jane Watson
• James Franco New Goblin / Harry Osborn
• Thomas Haden Church Sandman / Flint Marko
• Topher Grace Venom / Edward 'Eddie' Brock
• Bryce Dallas Howard Gwen Stacy
• Rosemary Harris May Parker
• J.K. Simmons J. Jonah Jameson
• James Cromwell Captain Stacy
• Theresa Russell Emma Marko
• Dylan Baker Dr. Curt Connors
• Bill Nunn Joseph 'Robbie' Robertson
• Bruce Campbell Maître d’
• Elizabeth Banks Betty Brant
• Ted Raimi Hoffman
• Willem Dafoe Norman Osborn
• Perla Haney-Jardine Penny Marko
• Cliff Robertson Ben Parker
• Elya Baskin Mr. Ditkovitch
• Mageina Tovah Ursula Ditkovitch
• John Paxton Bernard
• Stan Lee Man in Times Square
• Michael Papajohn Dennis Carradine, Carjacker
• Joe Manganiello Flash Thompson
• Hal Fishman Anchorman
• Lucy Gordon Jennifer Dugan
• Steve Valentine Photographer
• Tim Maculan Play Director
• Marc Vann Play Producer
• Joe Bays Jazz Club Manager
• Gregg Daniel Detective Neil Garrett
• Rogelio T. Ramos Emergency Room Doctor
• Timothy Patrick Quill Crane Operator
• Menachem Mendel Boymelgreen Kid in Times Square
• Nasir Stewart Kid in Times Square
• Austin Hendrickson Kid in Times Square
• Taylor Hemhauser Kid in Times Square
• Kathryn Bryding Woman Outside Theater
• Joe Virzi Police Detective
• Bill E. Rogers New Jersey State Policeman #1
• Michael Alexander New Jersey State Policeman #2 (as Mike Alexander)
• April Parker-Jones Test Site Technician #1 (as April D. Parker)
• Edward Padilla Test Site Technician #2
• Robert Curtis Brown Test Site Technician #3
• Paul Terrell Clayton Test Site Technician #4 (as Terrell Clayton)
• Carolyn Neff Test Site Technician #5
• Christina Cindrich Test Site Technician #6
• Sonya Maddox ICU Nurse
• Andre B. Blake Crane Disaster Radio Policeman
• Derrick 'Phoenix' Thomas Cop at Crane Disaster (as Derrick Thomas)
• Jessi Collins Mary Jane's Replacement
• Michael McLaughlin Boy at Keys to the City Ceremony
• Anne Gartland Councilwoman
• Emilio Rivera Policeman at Sand Truck #1
• Keith Woulard Policeman at Sand Truck #2
• Reynaldo Gallegos Armored Car Driver
• Jim Coope Newsstand Patron #1
• Dean Edwards Newsstand Patron #2
• Margaret Laney Newsstand Patron #3
• Toni Wynne Congratulatory Woman at Daily Bugle
• Aimee Miles Coffee Shop Waitress
• Tanya Sinovec Jazz Club Waitress
• Mark Kubr Jazz Club Bouncer
• Emma Raimi Girl with Camera
• Lorne Raimi Boy at the Final Battle #1
• Henry Raimi Boy at the Final Battle #2
• Samantha Ressler Girl at the Final Battle
• Alan Cohn Jazz Club Musician
• Dan Callahan Jazz Club Musician
• Ron King Jazz Club Musician
• Carol Chaikin Jazz Club Musician
• Dan Cummings Jazz Club Musician
• Vance Hammond Jazz Club Musician
• Maya Rosewood Charlie's Mom
• Abbey Skinner Cafe Girl
• Michael Ciesla Photographer (uncredited)
• Shade Rupe City Hall Cheerer (uncredited)

Writers

• Sam Raimi
• Ivan Raimi
• Alvin Sargent
• Sam Raimi
• Ivan Raimi
• Stan Lee
• Steve Ditko

Producers

• Avi Arad
• Joseph M. Caracciolo
• Grant Curtis
• Kevin Feige
• Stan Lee
• Laura Ziskin